Cimorene

Well, I don't suffer from the same problem - I rarely wear hand-knitted socks against the skin, though; I have some fine merino socks and some merino terry socks which are finer and warmer respectively than any of our hand-knitted ones, although in both cases, uglier and less durable. When it comes to thick wool boot socks, like most people in Finland, I wear them throughout the winter with other socks underneath. On the occasions when I have worn fingering-weight wool against the feet with shoes instead of for lounging around the house, I found the texture of stitches a bit distracting but not really uncomfortable.

The heel definitely is more snug than a regular hand-knitted sock, but it has a slight tendency to slide down towards the toe, at least on me - but this is probably partly due to the shape of the foot and ankle, I suppose.

How distinctly one feels the texture and also how uncomfortable that feeling is also probably varies a lot. A softer and less tightly-wound yarn in a luxurious blend like with yak, cashmere, and/or alpaca would make it much harder to feel the stitches, although the socks may pay for this by sliding down all the time (which is why I eventually gave up on making more socks out of Sandnes Garn's Spøt, which feels pretty heavenly on my feet - they just don't have enough elasticity compared to wool... merino is still very elastic, but the very fineness of the fiber means that it has to be tightly wound in order to have durability, which is important in socks, so while it is very soft, it's also springy and creates good stitch definition).